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RXFP1 receptor agonist-8 (Example 2) is a RXFP1 receptor agonist. RXFP1 receptor agonist-8 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 1.8 nM[1]. | [References]
[1] Jones, Clifford D., et al. Prepration of pyridopyrimidines as KRAS mutant proteins inhibitors useful in treatment of cancers. Patent. WO2022248885. |
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