| Identification | Back Directory | [Name]
GIC-20 | [CAS]
2942242-60-4 | [Synonyms]
GIC-20
2-Thiopheneacetamide, α-[(2-chloroacetyl)[4-[[6-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-1-oxohexyl]amino]phenyl]amino]-N-(2-phenylethyl)- | [MOL File]
2942242-60-4.mol | [Molecular Weight]
697.24 |
| Hazard Information | Back Directory | [Uses]
GIC-20 is a dual inducer for apoptosis and ferroptosis. GIC-20 exhibits antitumor efficacy against fibrosarcoma[1]. | [in vivo]
GIC-20 (20-40 mg/kg, i.p., once daily for 19 days) exhibits antitumor efficacy in HT1080 xenograft BALB/c mice, without significant toxicity in major organs[1]. | Animal Model: | HT1080 xenograft BALB/c mice[1] | | Dosage: | 20-40 mg/kg | | Administration: | i.p., once a day for 19 days | | Result: | Inhibited tumor growth, with a TGI of 63% at 40 mg/kg.
Maintained a complete morphology without obvious cellular inflammatory, oedema, or necrosis in major organs. |
| [References]
[1] Ma F, et al., ML162 derivatives incorporating a naphthoquinone unit as ferroptosis/apoptosis inducers: Design, synthesis, anti-cancer activity, and drug-resistance reversal evaluation. Eur J Med Chem. 2024 Apr 15;270:116387. DOI:10.1016/j.ejmech.2024.116387 |
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