| Identification | Back Directory | [Name]
HDAC-IN-60 | [CAS]
2944459-58-7 | [Synonyms]
HDAC-IN-60
Acetamide, N-hydroxy-2-[[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenyl]amino]- | [Molecular Formula]
C20H26N2O6 | [MOL File]
2944459-58-7.mol | [Molecular Weight]
390.43 |
| Hazard Information | Back Directory | [Uses]
HDAC-IN-60 (compound 21a) is a potent histone deacetylase (HDAC) inhibitor. HDAC-IN-60 can promote the intracellular generation of ROS, cause DNA damage, block the cell cycle at G2/M phase, and activate the mitochondria-related apoptotic pathway to induce cell apoptosis[1]. | [References]
[1] Yang Y, et, al. Design, Synthesis, and Biological Evaluation of Histone Deacetylase Inhibitors Derived from Erianin and Its Derivatives. ChemMedChem. 2023 Jul 3;18(13):e202300108. DOI:10.1002/cmdc.202300108 |
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