| Identification | Back Directory | [Name]
GP130-IN-1 | [CAS]
2955243-69-1 | [Synonyms]
GP130-IN-1
Methanone, [5-hydroxy-2-(4-hydroxyphenyl)-1H-indol-1-yl](2,3,4,5,6-pentafluorophenyl)- | [Molecular Formula]
C21H10F5NO3 | [MOL File]
2955243-69-1.mol | [Molecular Weight]
419.3 |
| Hazard Information | Back Directory | [Uses]
GP130-IN-1 (compound 49) is a potent GP130 inhibitor with significant in vitro antitumor activity and higher selectivity than Bazedoxifene (HY-A0031). GP130-IN-1 induces ultrastructural changes in cells, causing cell cycle arrest in the G0/G1 phase in a time-dependent manner and triggering apoptosis and autophagy. GP130-IN-1 can be used in the study of triple-negative breast cancer[1]. | [References]
[1] Wu P, et al. Structurally diverse design and synthesis of novel 2-phenylindole amide derivatives with anti-canine breast cancer activity[J]. Bioorganic Chemistry, 2024: 107788. DOI:10.1016/j.bioorg.2024.107788 |
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