| Identification | Back Directory | [Name]
SAKURANETIN | [CAS]
2957-21-3 | [Synonyms]
Nsc 407228
SAKURANETIN
SAKURANETIN(P)
SAKURANETIN(SH)
Sakura Pavilion
SAKURANETIN hplc
Einecs 220-980-5
(-)-(S)-sakuranetin
7-O-Methylnaringenin
Naringen 7-methyl ether
Naringenin 7-O-methyl ether
4',5-DIHYDROXY-7-METHOXYFLAVANONE
5,4''-DIHYDROXY-7-METHOXYFLAVANONE
5,4'-DIHYDROXY-7-O-METHOXYFLAVANONE
(S)-(?)-4′-5-Dihydroxy-7-methoxyflavanone
5,4''-DIHYDROXY-7-METHOXYFLAVANONE WITH HPLC
Flavanone, 4',5-dihydroxy-7-methoxy-, (S)-(-)- (8ci)
5,4''-DIHYDROXY-7-METHOXYFLAVANONE MONOHYDRATE WITH HPLC
(S)-5-Hydroxy-2-(4-hydroxyphenyl)-7-methoxychroman-4-one
2α-(4-Hydroxyphenyl)-7-methoxy-5-hydroxy-2,3-dihydro-4H-1-benzopyran-4-one
(S)-2,3-Dihydro-2-(4-hydroxyphenyl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one
(S)-2,3-Dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-, (2S)-
4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-, (S)- (9ci) | [EINECS(EC#)]
220-980-5 | [Molecular Formula]
C16H14O5 | [MDL Number]
MFCD00075651 | [MOL File]
2957-21-3.mol | [Molecular Weight]
286.28 |
| Chemical Properties | Back Directory | [Melting point ]
153-154°C | [alpha ]
D16 +8.0° (c = 7.92 in acetone); D12 +8.4° (c = 6.28 in methanol) | [Boiling point ]
555.9±50.0 °C(Predicted) | [density ]
1.370±0.06 g/cm3(Predicted) | [storage temp. ]
Store at 2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
neat | [pka]
7.42±0.40(Predicted) | [color ]
White to Off-White | [Cosmetics Ingredients Functions]
SKIN PROTECTING | [InChI]
InChI=1S/C16H14O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-7,14,17-18H,8H2,1H3/t14-/m0/s1 | [InChIKey]
DJOJDHGQRNZXQQ-AWEZNQCLSA-N | [SMILES]
[C@H]1(C2=CC=C(O)C=C2)OC2=CC(OC)=CC(O)=C2C(=O)C1 | [LogP]
3.370 (est) |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Prunus serrulata, a plant of the genus Prunus in the Rosaceae family. | [Uses]
Sakuranetin is a flavanone phytoalexin reported to play an important role in disease resistance in rice plants. Antifungal and antimicrobial activity. | [in vivo]
Sakuranetin (20 mg/kg, intratracheal instillation, 10 μL) reduces inflammation, and reduces respiratory system elastance in an mice acute lung inflammation model induced by LPS[2].
Sakuranetin (20 mg/kg, intratracheal instillation) attenuates airway hyperresponsiveness and inflammation in Ovalbumin induced asthma murine model[5].
| Animal Model: | Acute lung inflammation mice model induced by LPS (5 mg/kg)[2] | | Dosage: | 20 mg/kg | | Administration: | intratracheal instillation, 10 μL | | Result: | Reduced respiratory system elastance.
Decreased LPS-induced blood and pulmonary leukocytes.
Reduced proinflammatory cytokines, markers of M1- and M2-like macrophages, and activation of NF-κB in lung tissue. |
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