| Chemical Properties | Back Directory | [storage temp. ]
-20°C (des.) | [solubility ]
Soluble in DMSO (greater than 10 mg/ml) | [form ]
solid | [color ]
Purple | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
Geldanamycin-FITC is a novel geldanamycin fluorescent probe1?that may be used in a fluorescence polarization assay for HSP-90 inhibitors.2,3?May also be used for detection of cell surface HSP-90 and for other applications. Fluorescent geldanamycin probes have been used to characterize geldanamycin drug-target interactions for effective translation of?in vitro?pharmacology to cellular and?in vivo?efficacy.4 | [Uses]
Geldanamycin-FITC is a novel geldanamycin fluorescent probe. Fluorescent geldanamycin probes have been used to characterize geldanamycin drug-target interactions for effective translation of in vitro pharmacology to cellular and in vivo efficacy. | [IC 50]
HSP90 | [References]
1) Llauger-Bufi?et al. (2003),?Synthesis of novel fluorescent probes for the molecular chaperone Hsp90;? Bioorg. Med. Chem. Lett.,?13?3975
2) Kim?et al. (2004),?Development of a fluorescent polarization assay for the molecular chaperone Hsp90;? J. Biomol. Screen.,?9?375
3) Austin?et al. (2012),?Fragment screening using capillary electrophoresis (Defrag) for hit identification of heat shock protein 90 ATPase inhibitors;? J. Biomol. Screen.,?17?868
4) Gooljarsingh?et al. (2006),?A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues;? Proc. Natl. Acad. Sci. USA,?103?7625 |
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| Company Name: |
MO-CHEM Gold
|
| Telephone: |
13851755987 |
| Website: |
mo-chem.com |
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