2971769-60-3

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2971769-60-3 Structure

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[Uses] BBO-10203 (Compound 758) binds to the RBD region of PI3Kα, and inhibits the binding of K-, H-, and N-Ras to PI3Kα. BBO-10203 inhibits pAKT with an IC50 < 0.1 pM in BT474 cell[1].
[References] [1] Xu R. et al., Compounds having a t-structure formed by at least four cycles for use in the treatment of cancer and other indications. WO2023154282.

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