| Identification | Back Directory | [Name]
2-UNDECYL-THIAZOLIDINE-4-CARBOXYLIC ACID | [CAS]
298186-80-8 | [Synonyms]
BML-241
CAY10444
CAY10444 Exclusive
FNBSOIBCKUUVJJ-LSLKUGRBSA-N
2-UNDECYL-THIAZOLIDINE-4-CARBOXYLIC ACID
2-Undecylthiazolidine-4(R)-carboxylic acid
(4R)-2-Undecyl-4-thiazolidinecarboxylic acid
(4R)-2-Undecyl-4-thiazolidinecarboxylic acid >=98% (HPLC) | [Molecular Formula]
C15H29NO2S | [MDL Number]
MFCD08062140 | [MOL File]
298186-80-8.mol | [Molecular Weight]
287.46 |
| Chemical Properties | Back Directory | [Boiling point ]
439.2±40.0 °C(Predicted) | [density ]
1.017±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >5mg/mL | [form ]
powder | [pka]
2.09±0.40(Predicted) | [color ]
white to off-white |
| Hazard Information | Back Directory | [Uses]
CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca2+ in HeLa cells expressing S1P3 receptors[1]. | [Definition]
ChEBI: 4-thiazolidinecarboxylic acid, 2-undecyl-, (4r)- is a L-alpha-amino acid. | [Biological Activity]
CAY10444 is a selective sphingosine-1-phosphate (S1P) receptor 3 (S1P3; EDG3) antagonist th at inhibits 1 μM S1P-induced calcium mobilization in HeLa transfectants th at express S1P3 over those expressing S1P1/CD363/EDG1 (37.6% vs 6.92% inhibition by 10 μM CAY10444). | [IC 50]
S1PR3 | [References]
[1] Salvatore Salomone, et al. Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects. Front Pharmacol. 2011 Feb 22;2:9. DOI:10.3389/fphar.2011.00009 |
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