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2984236-79-3

2984236-79-3 Structure

2984236-79-3 Structure
IdentificationBack Directory
[Name]

PROTAC KRAS G12C degrader-1
[CAS]

2984236-79-3
[Synonyms]

PROTAC KRAS G12C degrader-1
[Molecular Formula]

C50H54ClFN8O6
[MOL File]

2984236-79-3.mol
[Molecular Weight]

917.47
Chemical PropertiesBack Directory
[density ]

1.354±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[pka]

8.41±0.40(predicted)
[color ]

Light yellow to green yellow
Hazard InformationBack Directory
[Uses]

PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C PROTAC degrader. PROTAC KRAS G12C degrader-1 induces CRBN/ KRASG12C dimerization and degrades GFP- KRASG12C in reporter cells[1].
[References]

[1] Zeng M, et, al. Exploring Targeted Degradation Strategy for Oncogenic KRAS G12C. Cell Chem Biol. 2020 Jan 16;27(1):19-31.e6. DOI:10.1016/j.chembiol.2019.12.006
2984236-79-3 suppliers list
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
Website: https://www.chemhifuture.com/
Company Name: Aikon International Limited  
Tel: 025-58859352 18651614124
Website: www.aikonchem.com/
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