| Identification | Back Directory | [Name]
Ro 67-7476 | [CAS]
298690-60-5 | [Synonyms]
Ro 67-7476
RO67-7476;RO-67-7476
(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine
Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)- | [Molecular Formula]
C17H18FNO2S | [MDL Number]
MFCD20270617 | [MOL File]
298690-60-5.mol | [Molecular Weight]
319.39 |
| Chemical Properties | Back Directory | [Boiling point ]
452.9±55.0 °C(Predicted) | [density ]
1.268±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO:30.0(Max Conc. mg/mL);93.9(Max Conc. mM) | [form ]
Powder | [pka]
-5.53±0.40(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 μM). It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 μM. Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices. It activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50 = 163.3 nM). | [Uses]
Ro 67-7476 is a positive allosteric metabotropic mGlu1 receptor modulator. | [IC 50]
mGluR1a: 60.1 nM (EC50) | [storage]
Store at RT | [References]
[1] F. KNOFLACH. Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site[J]. Proceedings of the National Academy of Sciences of the United States of America, 2001, 98 1: 13402-13407. DOI: 10.1073/pnas.231358298
[2] DOUGLAS J. SHEFFLER P. J C. Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells[J]. Neuropharmacology, 2008, 55 4: Pages 419-427. DOI: 10.1016/j.neuropharm.2008.06.047 |
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Musechem
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Twochem Co.Ltd.
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BOC Sciences
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