| Identification | Back Directory | [Name]
Methanone, (10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)[4-[3-(4-morpholinyl)propoxy]phenyl]- | [CAS]
2987640-67-3 | [Synonyms]
Methanone, (10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)[4-[3-(4-morpholinyl)propoxy]phenyl]- | [Molecular Formula]
C28H30N2O3 | [MOL File]
2987640-67-3.mol | [Molecular Weight]
442.55 |
| Chemical Properties | Back Directory | [Boiling point ]
622.8±55.0 °C(predicted) | [density ]
1.184±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
7.09±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
Cav 2.2/3.2 blocker 1 (Compound 9e) is a neuronal calcium channel blocker with IC50 values of 78 μM and 80 μM against Cav2.2 and Cav3.2, respectively. Cav 2.2/3.2 blocker 1 can penetrate the CNS[1]. | [IC 50]
Cav3.2: 80 μM (IC50); CaV2.2: 78 μM (IC50) | [References]
[1] Cardoso FC, et al. The neuronal calcium ion channel activity of constrained analogues of MONIRO-1. Bioorg Med Chem. 2020 Sep 15;28(18):115655. DOI:10.1016/j.bmc.2020.115655 |
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