| Identification | Back Directory | [Name]
18,21-Didehydro-17-demethoxy-18,21-dideoxo-4,5-dihydro-18-hydroxygeldanamycin | [CAS]
299173-64-1 | [Synonyms]
18,21-Didehydro-17-demethoxy-18,21-dideoxo-4,5-dihydro-18-hydroxygeldanamycin | [Molecular Formula]
C28H42N2O7 | [Molecular Weight]
518.64 |
| Chemical Properties | Back Directory | [Melting point ]
246 °C | [Boiling point ]
733.5±60.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
9.60±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
17-Demethoxy-reblastatin (17-DR) is an inhibitor for heat shock protein 90 (Hsp90), with an IC50 of 1.82 μM for yeast Hsp90 ATPase. 17-Demethoxy-reblastatin inhibits the proliferation of cancer cell HepG2 and SMMC7721, reduces the colony formation, and induces apoptosis through mitochondria and caspase mediated pathway[1]. | [References]
[1] Zhao S, et al., 17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells. J Bioenerg Biomembr. 2015 Oct;47(5):373-81. DOI:10.1007/s10863-015-9620-1 |
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