| Identification | Back Directory | [Name]
3-(5-amino-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)piperidine-2,6-dione | [CAS]
2991817-99-1 | [Synonyms]
3-(5-amino-3-methyl-1-oxo-3,4-dihydrophthalazin-2(1H)-yl)piperidine-2,6-dione
2,6-Piperidinedione, 3-(5-amino-3,4-dihydro-3-methyl-1-oxo-2(1H)-phthalazinyl)- | [Molecular Formula]
C14H16N4O3 | [MOL File]
2991817-99-1.mol | [Molecular Weight]
288.3 |
| Chemical Properties | Back Directory | [density ]
1.397±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
10.75±0.40(predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
MGD-4 is an orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=67.2 nM), IKZF2 (DC50=918.2 nM), and IKZF3 (DC50=95.8 nM) in a dose-dependent manner. MGD-4 effectively inhibits the growth of multiple myeloma[1]. | [IC 50]
IKZF1: 67.2 nM (DC50); IZKF2: 918.2 nM (DC50); IKZF3: 95.8 nM (DC50) | [References]
[1] Li P, et al. Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation[J]. Journal of Hematology & Oncology, 2024, 17(1): 77. DOI:10.1186/s13045-024-01592-z |
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