| Identification | Back Directory | [Name]
(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE | [CAS]
300543-56-0 | [Synonyms]
Levocetirizine Impurity 2
Levocetirizine Impurity A
(R)-Cetirizine EP Impurity A
(R)-1-[(4-Chlorophenyl)phenylmethyl
(R)-1-(p-Chlorobenzhydryl)piperazine
(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE
(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine
(R)-1-[^a-(4-Chlorophenyl)benzyl]piperazine,97%
(R)-(-)-1-[(4-chlorophenyl)phenmethyl]piperazine
Levocetirizine Chlorobenzhydryl Piperazine (USP)
Piperazine,1-[(R)-(4-chlorophenyl)phenylMethyl]-
(R)-1-[^a-(4-Chlorophenyl)benzyl]piperazine, 97%
(R)-(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
(R)-Cetirizine EP Impurity A (Levocetirizine Impurity 2)
(130018-88-1) (-)-1-((4-chlorophenyl)phenylmethyl)piperazine
(R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine (Cetirizine Impurity) | [EINECS(EC#)]
608-439-5 | [Molecular Formula]
C17H19ClN2 | [MDL Number]
MFCD08235114 | [MOL File]
300543-56-0.mol | [Molecular Weight]
286.8 |
| Chemical Properties | Back Directory | [Melting point ]
91-93oC | [Boiling point ]
409.1±0.0 °C(Predicted) | [density ]
1.158 | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
8.99±0.10(Predicted) | [color ]
White | [PH]
9.38 at 25℃ and 10.07g/L | [Water Solubility ]
Soluble in chloroform, methanol, and dichloromethane. Slightly soluble in water. | [InChI]
InChI=1/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2/t17-/s3 | [InChIKey]
UZKBSZSTDQSMDR-SCBJWRGWNA-N | [SMILES]
[C@@H](N1CCNCC1)(C1C=CC=CC=1)C1C=CC(Cl)=CC=1 |&1:0,r| | [CAS DataBase Reference]
300543-56-0 |
| Hazard Information | Back Directory | [Uses]
Intermediate in the production of (R)-Cetirizine (C281106). | [Application]
(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine could be used to synthesize a series of novel derivatives. Most of these derivatives significantly affected both allergic asthma and allergic itching. Meanwhile, in the test of allergic itching, five of the 19 compounds have more potent activities than levocetirizine[1].
| [References]
[1] Lisheng Wang. “Design, synthesis, and anti-allergic activities of novel (R)(-)-1-[(4-chlorophenyl)phenyl methyl]piperazine derivatives.” Medicinal Chemistry Research 21 1 (2010): 124–132.
|
|
|