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14α-Demethylase-IN-1 (compound 2e) is a 14α-demethylase inhibitor and can be used as an antifungal agent. 14α-Demethylase-IN-1 (48 h) exhibits MIC50 values of 2.47 μM, 1.23 μM, 19.70 μM, and 19.70 μM for C. albicans, C. parapsilosis, C. krusei, and C. glabrata, respectively[1]. | [References]
[1] Sazan Haji Ali, et al. Design, Synthesis, Investigation, and Biological Activity Assessments of (4-Substituted-Phenyl)- N-(3-morpholinopropyl)-3-phenylthiazol-2(3 H)-imine Derivatives as Antifungal Agents. ACS Omega. 2024 Sep 16;9(38):39326-39343. DOI:10.1021/acsomega.3c07879 |
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