| Chemical Properties | Back Directory | [Boiling point ]
600.865±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.267±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
16.440±0.30(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TFEB activator 2 (compound 37) exhibits TFEB activation and lysosome biogenesis capabilities. TFEB activator 2 has effect on TFEB nuclear translocation with 72% (10μM 3h) and 94 % (30 μM 3h). TFEB activator 2 plays an important role in Alzheimer’s disease (AD). TFEB activator 2 can pass blood brain barrier[1]. | [References]
[1] Jianhui Zhou, et al. Discovery and Optimization of Tetrahydroisoquinoline Derivatives To Enhance Lysosome Biogenesis as Preclinical Candidates for the Treatment of Alzheimer’s Disease. J Med Chem. 2024 Jun 13;67(11):8836-8861. DOI:10.1021/acs.jmedchem.4c00159 |
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