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3028774-14-0

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3028774-14-0 Structure

3028774-14-0 Structure
IdentificationBack Directory
[Name]

DCLK1-IN-5
[CAS]

3028774-14-0
[Synonyms]

DCLK1-IN-5
[Molecular Formula]

C26H32ClN7O3S2
[MOL File]

3028774-14-0.mol
[Molecular Weight]

590.16
Chemical PropertiesBack Directory
[Boiling point ]

741.678±70.00 °C(Press: 760.00 Torr)(predicted)
[density ]

1.390±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[pka]

12.804±0.20(predicted)
Hazard InformationBack Directory
[Uses]

DCLK1-IN-5 (Compound a24) is a DCLK1 inhibitor (IC50: 179.7 nM). DCLK1-IN-5 inhibits lipopolysaccharide (HY-D1056)-induced inflammation via inhibiting DCLK1-mediated IKKβ phosphorylation. DCLK1-IN-5 protects mice against inflammation-induced lung injury and sepsis[1].
[References]

[1] Cai B, et al. Discovery of a doublecortin-like kinase 1 inhibitor to prevent inflammatory responses in acute lung injury. Bioorg Chem. 2024 Apr;145:107215.
3028774-14-0 suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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