| Identification | Back Directory | [Name]
CITRIC ACID-1,5-13C2 | [CAS]
302912-06-7 | [Synonyms]
CITRIC ACID-1,5-13C2
CITRIC ACID (1,5-13C2, 98%)
Citric acid-1,5-13C2 98 atom % 13C
CITRIC-1,5-13C2 ACID, 99 ATOM % 13C | [Molecular Formula]
C6H8O7 | [MDL Number]
MFCD01321401 | [MOL File]
302912-06-7.mol | [Molecular Weight]
194.1 |
| Chemical Properties | Back Directory | [Melting point ]
153-159 °C (lit.) | [form ]
solid | [InChI]
1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/i3+1,4+1 | [InChIKey]
KRKNYBCHXYNGOX-CQDYUVAPSA-N | [SMILES]
OC(=O)C(O)(C[13C](O)=O)C[13C](O)=O | [CAS Number Unlabeled]
77-92-9 |
| Hazard Information | Back Directory | [Uses]
Citric acid-13C3 is the 13C labeled Citric acid[1]. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[2][3][4]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82. DOI:10.1007/s10616-013-9567-1
[3] Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan90(1):38-44. DOI:10.3109/10520295.2014.937745
[4] Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct33(10):4411-20. PMID:24123010 |
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