| Identification | Back Directory | [Name]
And1 degrader 1 | [CAS]
3029132-46-2 | [Synonyms]
And1 degrader 1
Phenol, 4-[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2-[[[4-(4-methyl-1-piperazinyl)phenyl]amino]methyl]- | [Molecular Formula]
C26H27Cl2N3O | [MOL File]
3029132-46-2.mol | [Molecular Weight]
468.42 |
| Chemical Properties | Back Directory | [Boiling point ]
641.6±55.0 °C(predicted) | [density ]
1.306±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
9.55±0.50(predicted) |
| Hazard Information | Back Directory | [Uses]
And1 degrader 1 (Compound A15) is a degrader of the acidic nucleoplasmic DNA-binding protein 1 (And1), which can significantly induce the degradation of And1 in NSCLC cells. And1 degrader 1 (5 μM) combined with Olaparib (HY-10162) (1 μM) effectively inhibits the proliferation of A549 and H460 cells. And1 degrader 1 can be used in cancer research[1]. | [References]
[1] Chen L, et al. Design, synthesis, and evaluation of novel stilbene derivatives that degrade acidic nucleoplasmic DNA-binding protein 1 (And1) and synergize with PARP1 inhibitor in NSCLC cells. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2383886. DOI:10.1080/14756366.2024.2383886 |
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