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3029897-97-7

3029897-97-7 Structure

3029897-97-7 Structure
IdentificationBack Directory
[Name]

3-Pyridinecarboxamide, N-[4-[[5-[3-[(dimethylamino)methyl]phenyl]-6-(1-methyl-1H-pyrazol-4-yl)furo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-
[CAS]

3029897-97-7
[Synonyms]

3-Pyridinecarboxamide, N-[4-[[5-[3-[(dimethylamino)methyl]phenyl]-6-(1-methyl-1H-pyrazol-4-yl)furo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-
[Molecular Formula]

C37H30FN7O4
[MOL File]

3029897-97-7.mol
[Molecular Weight]

655.68
Chemical PropertiesBack Directory
[Boiling point ]

822.8±65.0 °C(predicted)
[density ]

1.34±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

11.31±0.70(predicted)
Hazard InformationBack Directory
[Uses]

BPR5K230 is a dual inhibitor for the receptor tyrosine kinase MER and AXL, with IC50 of 4.1 nM and 9.2 nM. BPR5K230 inhibits the proliferation of Ba/F3-MER with IC50 of 5 nM. BPR5K230 exhibits good pharmacokinetic characteristics in mice, exhibits anti-inflammatory and antitumor against 4T1, MDA-MB-231, MC38 and Hepa1?6 in mouse models[1].
[References]

[1] Li MC, et al., Discovery of Dual MER/AXL Kinase Inhibitors as Bifunctional Small Molecules for Inhibiting Tumor Growth and Enhancing Tumor Immune Microenvironment. J Med Chem. 2024 Jun 24. DOI:10.1021/acs.jmedchem.4c00400
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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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