Identification | Back Directory | [Name]
3-Pyridinecarboxamide, N-[4-[[5-[3-[(dimethylamino)methyl]phenyl]-6-(1-methyl-1H-pyrazol-4-yl)furo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-1-(4-fluorophenyl)-1,2-dihydro-2-oxo- | [CAS]
3029897-97-7 | [Synonyms]
3-Pyridinecarboxamide, N-[4-[[5-[3-[(dimethylamino)methyl]phenyl]-6-(1-methyl-1H-pyrazol-4-yl)furo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-1-(4-fluorophenyl)-1,2-dihydro-2-oxo- | [Molecular Formula]
C37H30FN7O4 | [MOL File]
3029897-97-7.mol | [Molecular Weight]
655.68 |
Hazard Information | Back Directory | [Uses]
BPR5K230 is a dual inhibitor for the receptor tyrosine kinase MER and AXL, with IC50 of 4.1 nM and 9.2 nM. BPR5K230 inhibits the proliferation of Ba/F3-MER with IC50 of 5 nM. BPR5K230 exhibits good pharmacokinetic characteristics in mice, exhibits anti-inflammatory and antitumor against 4T1, MDA-MB-231, MC38 and Hepa1?6 in mouse models[1]. | [References]
[1] Li MC, et al., Discovery of Dual MER/AXL Kinase Inhibitors as Bifunctional Small Molecules for Inhibiting Tumor Growth and Enhancing Tumor Immune Microenvironment. J Med Chem. 2024 Jun 24. DOI:10.1021/acs.jmedchem.4c00400 |
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