| Identification | Back Directory | [Name]
SR 0987 | [CAS]
303126-97-8 | [Synonyms]
SR 0987
SR0987 >=98% (HPLC)
SR 0987;SR-0987;SR0987;303126-97-8
2-chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide
2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
Benzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]- | [Molecular Formula]
C16H10ClF6NO2 | [MDL Number]
MFCD02693203 | [MOL File]
303126-97-8.mol | [Molecular Weight]
397.7 |
| Chemical Properties | Back Directory | [Boiling point ]
378.8±42.0 °C(Predicted) | [density ]
1.525±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml) | [form ]
solid | [pka]
9.22±0.15(Predicted) | [color ]
White | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
SR 0987 is an agonist of the T cell-specific isoform of RORγ (RORγt, retinoic acid receptor-related orphan receptor-γt), inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA and ionomycin , increases expression of the RORγt target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged. Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987. | [Uses]
SR 0987 is a RORγt agonist. | [storage]
Store at -20°C | [References]
1) Chang?et al.?(2016),?Synthetic RORγt Agonists Enhance Protective Immunity;?ACS Chem. Biol.?11?1012 |
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| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Telephone: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
|