| Identification | Back Directory | [Name]
N,N-dimethylarginine | [CAS]
30315-93-6 | [Synonyms]
N,N-dimethylarginine
Asymmetric dimethylarginine
L-Arg(Me,Me)-OH(asymmetrical), >97%
N(omega),N(omega)-dimethyl-L-arginine
L-Ornithine, N5-[(dimethylamino)iminomethyl]-
Arginine Impurity 12（N, N-Dimethyl-L-Arginine）
N5-[(Dimethylamino)iminomethyl]-L-ornithine, 97%
(S)-2-Amino-5-(3,3-dimethylguanidino)pentanoic acid
N,N-dimethylarginine, 2-amino-5-(3,3-dimethylguanidino)pentanoic acid L-Arg(Me, Me)-OH (asymmetrical) | [Molecular Formula]
C8H18N4O2 | [MDL Number]
MFCD00038406 | [MOL File]
30315-93-6.mol | [Molecular Weight]
202.25 |
| Chemical Properties | Back Directory | [Boiling point ]
340.8±52.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMF: 5 mg/ml; DMSO: 3 mg/ml; Ethanol: 3 mg/ml; PBS (pH 7.2): freely soluble | [form ]
A crystalline solid | [pka]
2.50±0.24(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Metabolomics | [Definition]
ChEBI: A L-arginine derivative having two methyl groups both attached to the primary amino moiety of the guanidino group. | [General Description]
Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. Asymmetric dimethylarginine is created in protein methylation, a common mechanism of post-translational protein modification. This reaction is catalyzed by an enzyme set called S-adenosylmethionine protein N-methyltransferases (protein methylases I and II). The methyl groups transferred to create ADMA are derived from the methyl group donor S-adenosylmethionine, an intermediate in the metabolism of homocysteine. (Homocysteine is an important blood chemical, because it is also a marker of cardiovascular disease). After synthesis, ADMA migrates into the extracellular space and then into blood plasma. | [IC 50]
Human Endogenous Metabolite | [storage]
Store at -20°C, stored under nitrogen |
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