| Identification | Back Directory | [Name]
2-[[(4-Anilinophenyl)imino]methyl]-4,6-dichlorophenol | [CAS]
303215-67-0 | [Synonyms]
MitoBlock 6
2-[[(4-Anilinophenyl)imino]methyl]-4,6-dichlorophenol
2,4-Dichloro-6-[[[4-(phenylamino)phenyl]imino]methyl]phenol
Phenol, 2,4-dichloro-6-[[[4-(phenylamino)phenyl]imino]methyl]-
2,4-dichloro-6-[(E)-{[4-(phenylamino)phenyl]imino}methyl]phenol | [Molecular Formula]
C19H14Cl2N2O | [MDL Number]
MFCD00557142 | [MOL File]
303215-67-0.mol | [Molecular Weight]
357.23 |
| Chemical Properties | Back Directory | [Boiling point ]
535.1±50.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C (des.) | [solubility ]
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 6 mg/ml with warming). | [form ]
solid | [pka]
6.28±0.48(Predicted) | [color ]
Orange | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Description]
MitoBloCK-6 (303215-67-0) inhibits redox-regulated protein translocation into mitochondria. It attenuates the import of Erv1 substrates by inhibition of Erv1 oxidase activity (the import of Tim23 and AAC was decreased by ~50% at 20 μM). MitoBloCK-6 elucidated an unexpected role for Erv1 in the carrier import pathway, namely transferring substrates from the translocase of the outer membrane complex into the small Tim complexes. It impaired cardiac development in zebrafish embryos and induced apoptosis via the release of cytochrome c in human embryonic stem cells but not differentiated cells.1 | [Uses]
MitoBlock-6 is mitochondrial import inhibitor. It inhibits redox-regulated protein translocation into the mitochondria. | [in vivo]
MitoBloCK-6 (80 mg/kg, i.p., 5 of 7 days, twice daily) reduces tumor growth and the engraftment of AML cells into the marrow in mice xenografted with OCI-AML2 cells[4].
MitoBloCK-6 (80 mg/kg i.p. 5 of 7 days, 2 weeks) strongly reduces the engraftment of primary AML cells in mice[6].
| [References]
1) Dabir?et al. (2013),?A small molecule inhibitor of redox-regulated protein translocation into mitochondria; Dev. Cell,25?81 |
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Merck KGaA
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Carbosynth
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