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PARP-1/HDAC-IN-1 is a PARP-1/HDAC6 dual targeting inhibitor with IC50s of 68.90 nM and 510 nM, respectively. PARP-1/HDAC-IN-1 displays remarkable anticancer, anti-migration and anti-angiogenesis activities[1]. | [IC 50]
PARP-1: 68.90 nM (IC50); HDAC6: 510 nM (IC50); HDAC2: 42130 nM (IC50); HDAC3: 7220 nM (IC50) | [References]
[1] Ziwei Chi, et al. Design, synthesis and antitumor activity study of PARP-1/HDAC dual targeting inhibitors. Bioorg Med Chem Lett. 2022 Sep 1;71:128821. DOI:10.1016/j.bmcl.2022.128821 |
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