| Identification | Back Directory | [Name]
2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]- | [CAS]
3033018-68-4 | [Synonyms]
2(1H)-Isoquinolinepropanenitrile, 5-[[4-[[4-(1,6-dihydro-1,4,5-trimethyl-6-oxo-3-pyridinyl)-2,6-dimethoxyphenyl]methyl]-1-piperazinyl]methyl]-3,4-dihydro-1-methyl-β-oxo-α-[[4-(trifluoromethyl)-2-thiazolyl]methylene]- | [Molecular Formula]
C40H43F3N6O4S | [MOL File]
3033018-68-4.mol | [Molecular Weight]
760.87 |
| Chemical Properties | Back Directory | [Boiling point ]
856.3±75.0 °C(predicted) | [density ]
1.297±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
6.66±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
BRD9 Degrader-2 (Compound B11) is a BRD9 degrader (DC50 ≤1.25 nM; Dmax≥75%). BRD9 Degrader-2 can be used for research of cancers[1]. | [IC 50]
BRD9: <1.25 nM (DC50) | [References]
[1] David MCGARRY, et al. Compounds for targeted protein degradation. Patent. WO2024057021A1 |
|
|