3033570-20-3

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3033570-20-3 Structure

Identification	Back Directory
[Name] N-4′-(p-Trifluoromethylphenyl)butyl-DAB
[CAS] 3033570-20-3
[Synonyms] N-4′-(p-Trifluoromethylphenyl)butyl-DAB
[Molecular Formula] C16H22F3NO3
[MOL File] 3033570-20-3.mol
[Molecular Weight] 333.35

Chemical Properties	Back Directory
[Boiling point ] 457.2±45.0 °C(predicted)
[density ] 1.296±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 14.06±0.60(predicted)

Hazard Information	Back Directory
[Uses] N-4′-(p-Trifluoromethylphenyl)butyl-DAB (compound 5g) is an agonit of lysosomal acid α-glucosidase (GAA). N-4′-(p-Trifluoromethylphenyl)butyl-DAB increases intracellular GAA activities dose-dependently, in Pompe patient's fibroblasts with the M519V mutation[1].
[References] [1] Kato A, et al. Design and Pharmacological Chaperone Effects of N-(4'-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α-Glucosidase. J Med Chem. 2023 Jul 13;66(13):9023-9039. DOI:10.1021/acs.jmedchem.3c00637

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