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3037332-85-4

3037332-85-4 Structure

3037332-85-4 Structure
IdentificationBack Directory
[Name]

Benzamide, N-[(5-chloro-2-propoxyphenyl)methyl]-4-fluoro-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]-
[CAS]

3037332-85-4
[Synonyms]

Benzamide, N-[(5-chloro-2-propoxyphenyl)methyl]-4-fluoro-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]-
[Molecular Formula]

C28H28ClFN2O4S
[MOL File]

3037332-85-4.mol
[Molecular Weight]

543.05
Chemical PropertiesBack Directory
[Boiling point ]

697.6±65.0 °C(predicted)
[density ]

1.283±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

9.30±0.50(predicted)
Hazard InformationBack Directory
[Uses]

MS-II-124 is an effective and selective NLRP3 inhibitor (IC50=0.12 μM) with anti-inflammatory and immunomodulatory activities, which can be used in the research of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS)[1].
[in vivo]

MS-II-124 (10 mg/kg; i.p.; single dose) reduces lung inflammation and immune cell infiltration in the LPS (HY-D1056) ( i.n. instillation, 40 μg in 40 μL PBS) -induced ALI/ARDS wild-type mouse model, exhibiting anti-inflammatory and immunomodulatory activities[1].

Animal Model:ALI/ARDS WT C57BL/6 mice model[1].
Dosage:10 mg/kg
Administration:Intraperitoneal injection (i.p.), Single dose. 1 h before i.n. instillation of LPS (40 μg in 40 μL PBS).
Result:Significantly inhibited lipopolysaccharide (LPS)-induced IL-1β production in pulmonary bronchoalveolar lavage fluid (BALF), whereas NLRP3 deletion did not significantly inhibit its production.
[References]

[1] Xu Y, et al. Characterization of a small molecule inhibitor of the NLRP3 inflammasome and its potential use for acute lung injury[J]. Bioorganic Chemistry, 2024: 107562. DOI:10.1016/j.bioorg.2024.107562
3037332-85-4 suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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