| Identification | Back Directory | [Name]
[2S-(2alpha,5alpha,6beta)]-6-[[1,1'-biphenyl]-2-ylformamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | [CAS]
304-43-8 | [Synonyms]
Ancillin
Biphenicillin
Diphenicillin
([1,1'-Biphenyl]-2-yl)penicillin
6α-(2-Biphenylylcarbonylamino)penicillanic acid
6α-[([1,1'-Biphenyl]-2-ylcarbonyl)amino]penicillanic acid
(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylbenzoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2S,5R,6R)-7-keto-3,3-dimethyl-6-[(2-phenylbenzoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylphenyl)carbonylamino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[([1,1'-biphenyl]-2-ylcarbonyl)amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
[2S-(2alpha,5alpha,6beta)]-6-[[1,1'-biphenyl]-2-ylformamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | [EINECS(EC#)]
206-154-7 | [Molecular Formula]
C21H20N2O4S | [MDL Number]
MFCD01682155 | [MOL File]
304-43-8.mol | [Molecular Weight]
396.46 |
| Hazard Information | Back Directory | [Uses]
Diphenicillin (Ancillin (free acid); 2-Biphenylyl penicillin (free acid); SKF-12141 (free acid)) is a Penicillinase (HY-E70012)-
resistant penicillin with antibacterial activity. Diphenicillin shows good antibacterial effects against Gram-positive cocci. Diphenicillin is promising for research of infectious diseases caused by Gram-positive cocci such as staphylococci, pneumococci, and group A streptococci[1][2]. | [Safety Profile]
Moderately toxic by intravenousroute. Mildly toxic by ingestion. When heated todecomposition it emits very toxic fumes of NOx and SOx.See other penicillin entries. | [References]
[1] WEBER RG, et al. Clinical and laboratory studies of sodium diphenicillin. II. Clinical studies, with emphasis on the rate of disappearance of staphylococci from various lesions. Arch Intern Med. 1963 Jun;111:756-61. DOI:10.1001/archinte.1963.03620300076013
[2] Rudzit é A, et al. Ancillin. Synthesis and properties[J]. Pharmaceutical Chemistry Journal, 1967, 1(5): 245-246. |
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