| Identification | Back Directory | [Name]
Azidoacetyl Chloride | [CAS]
30426-58-5 | [Synonyms]
Azidoacetyl Chloride
2-azidoacetyl chloride | [Molecular Formula]
C2H2ClN3O | [MDL Number]
MFCD17013320 | [MOL File]
30426-58-5.mol | [Molecular Weight]
119.51 |
| Hazard Information | Back Directory | [Uses]
α-amino carbonyl equivalent suitable for the synthesis of amino azetidinones, has been widely used in the synthesis of β-lactam antibiotics; can also be used to acylate a variety of nucleophiles to give amino acid derivatives.
| [Synthesis]
The Preparative Method of Azidoacetyl Chloride: prepared by azide displacement of halide from the corresponding haloacetic acid, followed by treatment with Thionyl Chloride[1-2]. | [Precautions]
α-azido carbonyls have been identified as explosives and, as such, should be treated with extreme caution. Use in a fume hood.
| [References]
1. Hoppe, D.; Kloft, M. LA 1980, 1512.
2. Ojima, I.; Zhao, M.; Yamato, T.; Nakahashi, K.; Yamashita, M.; Abe, R. JOC 1991, 56, 5263
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