| Identification | Back Directory | [Name]
3-FLUORO-4-BROMO-ACETOPHENONE | [CAS]
304445-49-6 | [Synonyms]
3-FLUORO-4-BROMO-ACETOPHENONE
4-BROMO-3-FLUORO-ACETOPHENONE
3-Fluoro-4-bromo-caetophenone
4-Bromo-3-fluoroacetophenone,96%
1-(4-BroMo-3-fluorophenyl)ethanone
1-(4-broMo-3-fluorophenyl)ethan-1-one
Ethanone, 1-(4-broMo-3-fluorophenyl)-
6-acetyl-3-bromo-2-fluoro-1-cyclohexa-2,4-dienone | [Molecular Formula]
C8H6BrFO | [MDL Number]
MFCD00466241 | [MOL File]
304445-49-6.mol | [Molecular Weight]
217.04 |
| Chemical Properties | Back Directory | [Boiling point ]
263.3℃ | [density ]
1.535 | [Fp ]
113.0℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
Solid | [Appearance]
Off-white to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
A tetrahydrofuran solution of 3.00 M methylmagnesium chloride (125 mL, 0.38 mol) was added slowly and dropwise to a tetrahydrofuran (500 mL) solution of 4-bromo-3-fluoro-N-methoxy-N-methylbenzamide (58.5 g, 0.223 mol) at 0 °C. The reaction mixture was stirred continuously at 0 °C for 1 hour. Upon completion of the reaction, the reaction was quenched with pre-cooled saturated ammonium chloride solution (150 mL). The organic layer was separated and the remaining aqueous phase was extracted with ethyl acetate (3 x 50 mL). All organic phases were combined, washed with saturated brine, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford the crude product 3-fluoro-4-bromoacetophenone (48.4 g, 99% yield), which could be used in the subsequent reaction without further purification. | [References]
[1] Patent: US2008/39457, 2008, A1. Location in patent: Page/Page column 41
[2] Patent: WO2008/64157, 2008, A1. Location in patent: Page/Page column 42-43
[3] Patent: US2009/291956, 2009, A1. Location in patent: Page/Page column 19
[4] Patent: US2011/212967, 2011, A1. Location in patent: Page/Page column 8
[5] Patent: WO2012/48421, 2012, A1. Location in patent: Page/Page column 24 |
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