| Identification | Back Directory | [Name]
1H-Pyrazole-4-carboxaldehyde, 1-(2-methoxyethyl)- (9CI) | [CAS]
304693-70-7 | [Synonyms]
1-(2-methoxyethyl)pyrazole-4-carbaldehyde
1-(2-methoxyethyl)-4-pyrazole carbaldehyde
1-(2-methoxyethyl)-4-pyrazolecarboxaldehyde
1-(2-Methoxyethyl)-1H-pyrazol-4-carbaldehyde
1-(2-methoxyethyl)-1H-pyrazole-4-carboxaldehyde
1H-Pyrazole-4-carboxaldehyde, 1-(2-methoxyethyl)- (9CI) | [Molecular Formula]
C7H10N2O2 | [MDL Number]
MFCD13248693 | [MOL File]
304693-70-7.mol | [Molecular Weight]
154.17 |
| Chemical Properties | Back Directory | [Boiling point ]
269.8±20.0 °C(Predicted) | [density ]
1.14±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
-0.05±0.10(Predicted) | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
GENERAL STEPS: 1H-pyrazole-4-carbaldehyde (500 mg, 5.20 mmol) was dissolved in N,N-dimethylformamide (DMF, 20 mL), and 2-bromoethyl methyl ether (713 mg, 5.2 mmol) and cesium carbonate (Cs2CO3, 3.40 g, 10.4 mmol) were added in sequence. The reaction mixture was stirred at 60 °C overnight. After completion of the reaction, water (20 mL) was added to the mixture and extracted with ethyl acetate (EtOAc, 50 mL x 3). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford the target product 1-(2-methoxyethyl)-1H-pyrazole-4-carbaldehyde (520 mg, 65% yield). | [References]
[1] Patent: WO2018/50684, 2018, A1. Location in patent: Page/Page column 68
[2] Patent: WO2018/50686, 2018, A1. Location in patent: Page/Page column 72; 73 |
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