| Chemical Properties | Back Directory | [Boiling point ]
610.3±55.0 °C(predicted) | [density ]
1.187±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
9.00±0.28(predicted) |
| Hazard Information | Back Directory | [Uses]
Telomeric G4s ligand 1 is a telomeric G-quadruplex ligand that stabilizes telomeric G4 and induces R-loop formation, leading to DNA damage responses. Telomeric G4s ligand 1 induces apoptosis and evokes immunogenic cell death (ICD) in tumor cells[1]. | [in vivo]
Telomeric G4s ligand 1 (compound R1; 10 mg/kg; ip; every other day for 14 days) exhibits a significant decrease in tumor burden through the immunomodulatory effects, including the increase of CD4+ and CD8+ T cells in tumors and cytokine levels in sera in breast cancer mouse model[1]. | Animal Model: | 4-week-old female BALB/c mice injected 4T1 cells[1] | | Dosage: | 10 mg/kg | | Administration: | ip; every other day for 14 days | | Result: | Exhibited the ability to lengthen the survival time of tumor-bearing mice, and resulted in DNA damage and apoptosis in vivo.
|
| [References]
[1] Jia-Xin Wang, et al. Novel quinoxaline analogs as telomeric G-quadruplex ligands exert antitumor effects related to enhanced immunomodulation. Eur J Med Chem. 2024 Aug 5:274:116536. DOI:10.1016/j.ejmech.2024.116536 |
|
|