| Identification | Back Directory | [Name]
[1,1′-Biphenyl]-3-carboxylic acid, 3′-(cyclopropylmethoxy)-5-[(3-phenoxybenzoyl)amino]- | [CAS]
3048021-44-6 | [Synonyms]
[1,1′-Biphenyl]-3-carboxylic acid, 3′-(cyclopropylmethoxy)-5-[(3-phenoxybenzoyl)amino]- | [Molecular Formula]
C30H25NO5 | [MOL File]
3048021-44-6.mol | [Molecular Weight]
479.52 |
| Chemical Properties | Back Directory | [Boiling point ]
627.9±55.0 °C(predicted) | [density ]
1.296±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
3.95±0.10(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
FABP1-IN-1 (44) is a selective FABP1 inhibitor, with an IC50 of 4.46 μM. FABP1-IN-1 (44) can be used for the research of NASH[1]. | [in vivo]
FABP1-IN-1 (44) alleviates the typical histological features of fatty liver in NASH mice, including steatosis, lobular inflammation, ballooning and fibrosis[1].
| [References]
[1] Ya Chen, et al. Design, synthesis, and biological evaluation of first-in-class FABP1 inhibitors for the treatment of NASH. Eur J Med Chem. 2024 Apr 15:270:116358. DOI:10.1016/j.ejmech.2024.116358 |
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