| Chemical Properties | Back Directory | [Boiling point ]
834.091±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
0.942±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
Methyl Acetate: Soluble: =10 mg/ml | [pka]
14.405±0.10(predicted) |
| Hazard Information | Back Directory | [Description]
Lipid U 105 is an ionizable cationic lipid (pKa = 6.65) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of circular RNA in vitro and in vivo.1 LNPs containing lipid U 105 and encapsulating circular RNA encoding VEGF-A increase the levels of VEGF-A in, and increases the proliferation and migration of, human umbilical vein endothelial cells (HUVECs). Topical administration of the same LNPs increases wound healing in a mouse model of diabetes induced by a high-fat and -sugar diet.WARNING This product is not for human or veterinary use. | [References]
[1] A single dose of VEGF-A circular RNA sustains in situ long-term expression of protein to accelerate diabetic wound healing[J]. Journal of Controlled Release, 2024, 373: Pages 319-335. DOI: 10.1016/j.jconrel.2024.07.018 |
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