| Identification | Back Directory | [Name]
L-Histidine, N-[(1R)-1-carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]- | [CAS]
305335-29-9 | [Synonyms]
(R)-MLN-4760
L-Histidine, N-[(1R)-1-carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]- | [Molecular Formula]
C19H23Cl2N3O4 | [MOL File]
305335-29-9.mol | [Molecular Weight]
428.31 |
| Chemical Properties | Back Directory | [Boiling point ]
639.5±55.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 14.29 mg/mL (33.36 mM) | [form ]
Solid | [pka]
1.87±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(R)-MLN-4760, the R-enantiomer of MLN-4760, is an ACE2 inhibitor, with an IC50 of 8.4 μM. (R)-MLN-4760 is the less active isomer[1]. | [storage]
Store at -20°C | [References]
[1] Dales NA, et, al. Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. J Am Chem Soc. 2002 Oct 9;124(40):11852-3. DOI:10.1021/ja0277226 |
|
|