| Identification | Back Directory | [Name]
(+)-Bisabolangelone | [CAS]
30557-81-4 | [Synonyms]
Angelikoreanol
Bisabolangelon
Bisabplangelone
Bisabolangelone
(+)-Angelikoreanol
(+)-Bisabolangelone
4(2H)-Benzofuranone, 3,3a,7,7a-tetrahydro-3-hydroxy-3,6-dimethyl-2-(3-methyl-2-buten-1-ylidene)-, (2Z,3R,3aR,7aS)- | [Molecular Formula]
C15H20O3 | [MDL Number]
MFCD14105600 | [MOL File]
30557-81-4.mol | [Molecular Weight]
248.32 |
| Chemical Properties | Back Directory | [Melting point ]
157-158 °C | [Boiling point ]
396.0±42.0 °C(Predicted) | [density ]
1.154±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
14.54±0.40(Predicted) | [color ]
Off-white to yellow | [InChI]
InChI=1S/C15H20O3/c1-9(2)5-6-13-15(4,17)14-11(16)7-10(3)8-12(14)18-13/h5-7,12,14,17H,8H2,1-4H3/b13-6-/t12-,14+,15-/m0/s1 | [InChIKey]
GNWNPLBSEQDDQV-VRBKASCLSA-N | [SMILES]
O1[C@@]2([H])CC(C)=CC(=O)[C@@]2([H])[C@](O)(C)/C/1=C/C=C(/C)\C |
| Hazard Information | Back Directory | [Uses]
Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone possesses anti-inflammatory properties, which inhibits LPS-stimulated inflammation through the blocking of NF-kappaB and MAPK pathways in macrophages. Bisabolangelone has anti-ulcer activities[1][2]. | [storage]
4°C, protect from light | [References]
[1] Jung HW, et al. Bisabolangelone isolated from Ostericum koreanum inhibits the production of inflammatory mediators by down-regulation of NF-kappaB and ERK MAP kinase activity in LPS-stimulated RAW264.7 cells. Int Immunopharmacol. 2010 Feb;10(2):155-62. DOI:10.1016/j.intimp.2009.10.010
[2] Wang J, et al. The anti-ulcer activities of bisabolangelone from Angelica polymorpha. J Ethnopharmacol. 2009 Jun 22;123(2):343-6. DOI:10.1016/j.jep.2009.02.048 |
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cjbscvictory
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