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30685-57-5

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30685-57-5 Structure

30685-57-5 Structure
IdentificationBack Directory
[Name]

2,4(1H,3H)-Pyrimidinedione, 1-(5-deoxy-β-D-ribo-hexofuranosyl)-
[CAS]

30685-57-5
[Synonyms]

Homouridine
1-(5-Deoxy-β-D-ribo-hexofuranosyl)-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 1-(5-deoxy-β-D-ribo-hexofuranosyl)-
[Molecular Formula]

C10H14N2O6
[MOL File]

30685-57-5.mol
[Molecular Weight]

258.23
Chemical PropertiesBack Directory
[Melting point ]

105-107 °C
[density ]

1.591±0.06 g/cm3(Predicted)
[pka]

9.39±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

Homouridine, is an uridine analogue. Homouridine serves as an intermediate to prepare MMP-2 inhibitor (compund I, IC50=150 μM). Homouridine derivate (compund I) also inhibits TNF-α binding to TNF-αR1[1].
[References]

[1] Hsu Li-Wei, et al. Uridine derivatives as matrix metalloproteinase (MMP) and tumor necrosis factor (TNF) inhibitors for the treatment of cancer. European Patent Organization, EP1338282 A1. 2003-08-27.
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