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30711-93-4

30711-93-4 Structure

30711-93-4 Structure
IdentificationBack Directory
[Name]

1,3,5-Triazine-2,4-diamine,1,6-dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-, hydrochloride(1:1)
[CAS]

30711-93-4
[Synonyms]

WR99210 hydrochloride
WR99210 hydrochloride(47326-86-3 free base)
1,3,5-Triazine-2,4-diamine,1,6-dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-, hydrochloride(1:1)
[Molecular Formula]

C14H19Cl4N5O2
[MOL File]

30711-93-4.mol
[Molecular Weight]

431.14
Chemical PropertiesBack Directory
[storage temp. ]

-20°C
[solubility ]

DMSO: 2mg/mL, clear
[form ]

powder
[color ]

white to beige
Hazard InformationBack Directory
[Description]

BRL 6231 is a triazine antimalarial.
[Uses]

WR99210 hydrochloride is an orally active and low-toxicity dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 hydrochloride shows good antiparasitic activity and is effective against P. falciparum and P. falciparum strains as well as T. gondii[1][2][3].
[References]

[1] Mui EJ, et al. Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo. Antimicrob Agents Chemother. 2005 Aug;49(8):3463-7. DOI:10.1128/AAC.49.8.3463-3467.2005
[2] Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41. DOI:10.1073/pnas.182295999
[3] Kiara SM, et al. In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation. Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8. DOI:10.1128/AAC.00308-09
Spectrum DetailBack Directory
[Spectrum Detail]

1,3,5-Triazine-2,4-diamine,1,6-dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-, hydrochloride(1:1)(30711-93-4)1HNMR
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