| Identification | Back Directory | [Name]
4-HYDROXYALPRAZOLAM | [CAS]
30896-57-2 | [Synonyms]
4-Hydroxy Alprazolam Methanoate | [Molecular Formula]
C17H13ClN4O | [MDL Number]
MFCD00871804 | [MOL File]
30896-57-2.mol | [Molecular Weight]
324.77 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
160-1620C | [Boiling point ]
559.2±60.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
Controlled Substance, -20?C Freezer | [solubility ]
DMSO: 8 mg/ml | [form ]
White solid. | [pka]
11.59±0.40(Predicted) |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A metabolite of Alprazolam, a benzodiazepine.
Controlled Substance | [Description]
Alprazolam is a benzodiazepine with anxiolytic and sedative actions. 4-Hydroxyalprazolam is a major metabolite of alprazolam, produced by the actions of cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5. It may be detected in serum or, in a glucuronidated form, in urine. Alternatively, 4-hydroxyalprazolam can be further metabolized to benzophenone. | [Definition]
ChEBI: 4-Hydroxyalprazolam is a triazolobenzodiazepine. | [References]
[1] NORIKO HIROTA. In Vitro/in Vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans[J]. Biopharmaceutics & Drug Disposition, 2001, 22 2: 53-71. DOI: 10.1002/bdd.261
[2] J ANDREW WILLIAMS. Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.[J]. Drug Metabolism and Disposition, 2002, 20 1: 883-891. DOI: 10.1124/dmd.30.8.883 |
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Energy Chemical
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Merck KGaA
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DeBioChem
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