311315-04-5

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311315-04-5 Structure

Chemical Properties	Back Directory
[density ] 1.90±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[form ] Solid
[pka] 11.08±0.43(predicted)
[color ] Off-white to pink

Hazard Information	Back Directory
[Uses] AD16 (Acetamide) is a LINE-1 retrotransposon endonuclease inhibitor with the IC50 of 4.7 μM. AD16 (Acetamide) reduce LINE-1 retrotransposition, L1-induced DNA damage, and inflammation reinforced by L1 in senescent cells[1].
[References] [1] D'Ordine AM, et al. Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease. Nat Commun. 2024;15(1):3883. Published 2024 May 8. DOI:10.1038/s41467-024-48066-x

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