| Identification | Back Directory | [Name]
HEMICHOLINIUM-3 | [CAS]
312-45-8 | [Synonyms]
hc-3
Dibromide
hemicholine
hemicholiniumbromide
hemicholiniumdibromide
hemicholinium-3bromide
hemicholinium-3dibromide
2,2'-(4,4'-biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium) dibromide
2,2’-(4,4’-biphenylylene)bis(2-hydroxy-4,4-dimethyl-morpholiniudibromide
2,2’-(1,1’-biphenyl)-4,4’-diylbis(2-hydroxy-4,4-dimethyl-morpholinium)dibrom
2-[4-[4-(2-hydroxy-4,4-dimethylmorpholin-4-ium-2-yl)phenyl]phenyl]-4,4-dimethylmorpholin-4-ium-2-ol dibromide
2-[4-[4-(2-hydroxy-4,4-dimethyl-morpholin-4-ium-2-yl)phenyl]phenyl]-4,4-dimethyl-morpholin-4-ium-2-ol dibromide
HACU,Choline,receptor,system,Hemicholinium dibromide,Inhibitor,transporter,ACh,Nicotinic,Hemicholinium 3,Hemicholinium3,inhibit,nervous,Enteric,neuromuscular,acetylcholine,Cholinesterase (ChE) | [EINECS(EC#)]
206-227-3 | [Molecular Formula]
C24H34N2O4.2Br | [MDL Number]
MFCD00011978 | [MOL File]
312-45-8.mol | [Molecular Weight]
574.351 |
| Chemical Properties | Back Directory | [Melting point ]
180°; mp 226- 228° (dec) | [storage temp. ]
Store at -20°C | [solubility ]
ethanol: 1.3 mg/mL
| [form ]
solid
| [color ]
white
| [Water Solubility ]
Water : 33.33 mg/mL (58.03 mM; Need ultrasonic) | [Merck ]
13,4660 | [BRN ]
5704458 | [InChI]
1S/C24H34N2O4.2BrH/c1-25(2)13-15-29-23(27,17-25)21-9-5-19(6-10-21)20-7-11-22(12-8-20)24(28)18-26(3,4)14-16-30-24;;/h5-12,27-28H,13-18H2,1-4H3;2*1H/q+2;;/p-2 | [InChIKey]
OPYKHUMNFAMIBL-UHFFFAOYSA-L | [SMILES]
[Br-].[Br-].C[N+]1(C)CCOC(O)(C1)c2ccc(cc2)-c3ccc(cc3)C4(O)C[N+](C)(C)CCO4 | [EPA Substance Registry System]
Morpholinium, 2,2'-[1,1'-biphenyl]-4,4'-diylbis[2-hydroxy-4,4-dimethyl-, dibromide (312-45-8) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
23/24/25-36/37/38 | [Safety Statements ]
26-36/37/39-45 | [RIDADR ]
UN 2811 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
QF2450000
| [TSCA ]
TSCA listed | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | [Toxicity]
LD50 i.p. in female mice: 0.048-0.082 mg/kg (DiAugustine, Haarstad) |
| Hazard Information | Back Directory | [Uses]
Acetylcholine stores depletor | [Uses]
Research tool as cholinergic probe, to deplete acetylcholine stores. | [Biochem/physiol Actions]
Hemicholinium-3 plays a role in blocking the neuronal choline uptake thereby inhibiting acetylcholine synthesis in the brain. | [in vivo]
Hemicholinium-3 impairs spatial learning. Hemicholinium-3 (2.5, 5.0 μg/rat/ICV; 1 h before training) dose dependently impairs spatial learning[5]. |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|