| Identification | Back Directory | [Name]
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide | [CAS]
312917-14-9 | [Synonyms]
SC-20267
TCS JNK 5a
JNK Inhibitor IX
JNK Inhibitor IX, >=98%
TCS JNK 5a(JNK Inhibitor IX)
N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-naphthamide
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-1-naphthalenecarboxamide
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
1-NaphthalenecarboxaMide, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-1-naphthalenecarboxamide JNK Inhibitor IX | [Molecular Formula]
C20H16N2OS | [MDL Number]
MFCD01005305 | [MOL File]
312917-14-9.mol | [Molecular Weight]
332.419 |
| Chemical Properties | Back Directory | [Melting point ]
88-90oC | [Boiling point ]
486.8±45.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Store at RT | [solubility ]
Soluble in DMSO (up to 13 mg/ml with warming) or in Ethanol (up to 4 mg/ml with warming) | [form ]
Tan solid | [pka]
11.95±0.20(Predicted) | [color ]
Off-white | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. | [InChI]
1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23) | [InChIKey]
WQGDQGAFSDMBLA-UHFFFAOYSA-N | [SMILES]
[s]1c2c(c(c1NC(=O)c3c4c(ccc3)cccc4)C#N)CCCC2 |
| Hazard Information | Back Directory | [Description]
JNK inhibitor IX (312917-14-9) inhibits JNK2 and JNK3 via binding to the ATP binding domain. Displays little or no activity against JNK1, p38α and a panel of 30 other kinases.1?Induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells.2 | [Uses]
JNK Inhibitor IX is a potent and selective inhibitor of JNK2 and JNK3. Neuroresearch & Neuroprotective Product. | [Definition]
ChEBI: N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-naphthalenecarboxamide is a naphthalenecarboxamide. | [IC 50]
JNK3: 6.7 (pIC50); JNK2: 6.5 (pIC50) | [storage]
Store at RT | [References]
1) Angell?et al. (2007),?N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3; Med. Chem. Lett.,?17?1296
2) Jang?et al.?(2014),?Inhibition of JNK2 and JNK3 by JNK inhibitor IX induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells?; Biochem. Biophys. Res. Commun.,?452?845 |
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