| Identification | Back Directory | [Name]
CypHer5 | [CAS]
312961-83-4 | [Synonyms]
CypHer5
1H-Indole-1-hexanoic acid, 2-[5-(3,3-dimethyl-5-sulfo-3H-indol-2-yl)-2,4-pentadien-1-ylidene]-2,3-dihydro-3,3-dimethyl-5-sulfo- | [Molecular Formula]
C31H36N2O8S2 | [MOL File]
312961-83-4.mol | [Molecular Weight]
628.76 |
| Chemical Properties | Back Directory | [density ]
1.34±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
-1.47±0.60(Predicted) | [color ]
Brown to reddish brown | [InChIKey]
VRQVBVFJEIJSIE-UHFFFAOYSA-N | [SMILES]
N1(CCCCCC(O)=O)C2=C(C=C(S(O)(=O)=O)C=C2)C(C)(C)C1=CC=CC=CC1C(C)(C)C2=C(N=1)C=CC(S(O)(=O)=O)=C2 |
| Hazard Information | Back Directory | [Uses]
CypHer 5 is a pH-sensitive cyanine derivative and a environmental sensitive fluorophore. CypHer 5 has a pH-sensitive maximal absorption at 644 nm and emission at 664 nm. CypHer 5 has been used as a pH sensor of lysosomal compartments[1]. | [References]
[1] Patrick MJ, et al. Intracellular pH measurements using perfluorocarbon nanoemulsions. J Am Chem Soc. 2013 Dec 11;135(49):18445-57. DOI:10.1021/ja407573m
[2] Elaine J Adie, et al. CypHer 5: a generic approach for measuring the activation and trafficking of G protein-coupled receptors in live cells. Assay Drug Dev Technol. 2003 Apr;1(2):251-9. DOI:10.1089/15406580360545062 |
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