| Identification | Back Directory | [Name]
MYRISTOYL COENZYME A MONOHYDRATE* | [CAS]
3130-72-1 | [Synonyms]
Myristyl-CoA
MYRISTOYL-COA
Tetradecanoyl-CoA
Myristoyl-CoA-sodium-salt
s-tetradecanoyl-coenzymea
Tetradecanoyl coenzyme A
Coenzyme A, S-tetradecanoate
MYRISTOYL COENZYME A MONOHYDRATE*
coenzyme A myristoyl derivative, monohydrate
S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] tetradecanethioate
S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-azanylpurin-9-yl)-4-hydroxy-3-phosphonooxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] tetradecanethioate
[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-tetradecanoylsulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
tetradecanethioic acid S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] ester | [Molecular Formula]
C35H62N7O17P3S | [MDL Number]
MFCD00871327 | [MOL File]
3130-72-1.mol | [Molecular Weight]
977.89 |
| Hazard Information | Back Directory | [Uses]
Myristoyl coenzyme A is a myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms. | [Definition]
ChEBI: A long-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of myristic acid. | [IC 50]
Human Endogenous Metabolite | [References]
[1] Raju RV, et al. Coenzyme A dependent myristoylation and demyristoylation in the regulation of bovine spleen N-myristoyltransferase. Mol Cell Biochem. 1996 May 24;158(2):107-13. DOI:10.1007/BF00225835 |
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