| Identification | Back Directory | [Name]
mikamycin B | [CAS]
3131-03-1 | [Synonyms]
PA 114B
NSC 92554
mikamycin B
MikaMycin IA
Ostreogrycin B
Streptogramin B
VirginiaMycin B
Pristinamycin IA
PristinaMycin P 1
Antibiotic PA 114B
Antibiotic PA 114B1
PristinaMycin IA
DISCONTINUED
4-[4-(DiMethylaMino)-N-Methyl-L-phenylalanine]virginiaMycin S1
N-[(3-Hydroxy-2-pyridinyl)carbonyl]cyclo(L-Thr*-D-Abu-L-Pro-N-methyl-4-(dimethylamino)-L-Phe-4-oxo-L-2-piperidinecarbonyl-L-phenyl Gly-)
Ostreogrycin B, PristinaMycin IA, StreptograMin B, Syncothrecin B1, Synergistin B, VernaMycin Balpha, VirginiaMycin 1A, NSC 125176, 14725-1, PA 114B, RP 12535
N-[(3-Hydroxy-2-pyridinyl)carbonyl]-L-threonyl-(2R)-2-aMinobutanoyl-L-prolyl-4-(diMethylaMino)-N-Methyl-L-phenylalanyl-(2S)-4-oxo-2-piperidinecarbonyl-(2S)-2-phenylglycine (6-13)-lactone | [Molecular Formula]
C45H54N8O10 | [MDL Number]
MFCD30489790 | [MOL File]
3131-03-1.mol | [Molecular Weight]
866.958 |
| Chemical Properties | Back Directory | [Melting point ]
198° | [alpha ]
D22 -57.5° (c = 0.25 in ethanol) | [Boiling point ]
780.3°C (rough estimate) | [density ]
1.1881 (rough estimate) | [refractive index ]
1.6910 (estimate) | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
pKa 7.20±0.05(H2O,t =25,I=0.2(LiClO4)) (Uncertain) | [color ]
Pale Yellow | [Contact allergens]
Pristinamycin is a systemic antibiotic of the synergistins/
streptogramins class, composed of two subunits: pristinamycin
IA and pristinamycin IIA. It induces several
types of drug reactions such as maculo-papular exanthema,
systemic dermatitis, or acute generalized exanthematous
pustulosis. Some patients have been previously
skin-sensitized by virginiamycin. Crossreactivity
is expected to virginiamycin and to the associated dalfopristin
and quinupristin. |
| Hazard Information | Back Directory | [Uses]
One of the two major components of Pristinamycin (Pristinamycin IA and Pristinamycin IIA (or Virginiamycin M1-V673810). | [Uses]
Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A, together used as a synergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups, leading to considerable confusion in the literature. Virginiamycin B acts a synergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A. | [Uses]
Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A, together used as a syngergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups, leading to considerable confusion in the literature. Viriginiamycin B acts a syngergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A. | [Definition]
ChEBI: A cyclodepsipeptide that is (together with pristinamycin IIA) a component of pristinamycin, an oral streptogramin antibiotic produced by Streptomyces pristinaespiralis. Pristinamycin exhibits bactericidal activity against Gram positive organis
s including methicillin-resistant Staphylococcus aureus. | [IC 50]
Macrolide |
|
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