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Prodipine, a diphenyl-phosphonate derivative. The IC50s of Prodipine for purified and plasma Dipeptidyl peptidase IV (DPP IV) from the rabbit are 4.5 μM and 30 μM, respectively. | [Biological Activity]
Prodipine (hydrochloride) is a diphenylphosphonate derivative. Inhibits dipeptidyl peptidase IV (DPP IV) in purified rabbit and plasma with IC50 of 4.5 μM and 30 μM, respectively. | [in vitro]
Prodipine (hydrochloride), a diphenyl-phosphonate derivative selected from a group of slow-binding irreversible inhibitors of this enzyme. The IC 50 values of Prodipine for purified and plasma DPP IV from the rabbit are 4.5 μM and 30 μM, respectively. | [in vivo]
Male rabbits weighing 3-4 kg receive a single intravenous injection with 10 mg Prodipine (hydrochloride) or saline. After 1 hr, plasma DPP IV activity has decreased to less than 20% of the preinjection value and remains unchanged during a 24 hr observation period. A profound and long-lasting inhibition of plasma DPP IV activity is observed in the treated animals (1, 5 or 10 mg). It takes 5 to 8 days to reach half of the pretreatment DPP IV activity and generally more than 20 days for a complete recovery. | [target]
IC50: 4.5 μM (purified DPP IV), 30 μM (plasma DPP IV) | [IC 50]
DPP-4 | [storage]
Store at -20°C | [References]
[1] De Meester I, et al. In vivo inhibition of dipeptidyl peptidase IV activity by pro-pro-diphenyl-phosphonate (Prodipine). Biochem Pharmacol. 1997 Jul 1;54(1):173-9. DOI:10.1016/s0006-2952(97)00149-4 |
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A.J Chemicals
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MedChemExpress
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www.medchemexpress.com |
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