| Identification | Back Directory | [Name]
ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate | [CAS]
313254-94-3 | [Synonyms]
MMG-11
ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate | [Molecular Formula]
C15H14O7 | [MDL Number]
MFCD00499091 | [MOL File]
313254-94-3.mol | [Molecular Weight]
306.267 |
| Chemical Properties | Back Directory | [Boiling point ]
565.6±50.0 °C(Predicted) | [density ]
1.430±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (326.51 mM; Need ultrasonic) | [form ]
Solid | [pka]
7.05±0.40(Predicted) | [color ]
Light yellow to brown | [InChIKey]
IIDUJWIVMGALOG-UHFFFAOYSA-N | [SMILES]
O=C(OCC)C1=CC=C(O1)CC(C2=CC=C(C(O)=C2O)O)=O |
| Hazard Information | Back Directory | [Uses]
MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7?μM for Pam3CSK4-induced hTLR2/1 and 5.7?μM for Pam2CSK4-induced hTLR2/6 responses[1]. | [Biological Activity]
MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses[1].
MMG-11 neither shows cellular toxicity nor interference with signaling induced by other TLR agonists, IL-1β or TNF. MMG-11 (0.01-100 μM) shows no cytotoxic effects up to 100 μM in peripheral blood mononuclear cells (PBMCs)[1]. | [IC 50]
TLR2 | [storage]
Store at -20°C | [References]
[1]. Grabowski M, et al. Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem Pharmacol. 2018 Aug;154:148-160. |
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