| Identification | Back Directory | [Name]
1H-Indole-7-carbonitrile,4-fluoro-(9CI) | [CAS]
313337-33-6 | [Synonyms]
SW-9
SWF-9
7-Cyano-4-fluoroindole
7-Cyano-4-fluoro-1H-indole
4-Fluoroindole-7-carbonitrile
4-fluoro-1H-indole-7-carbonitrile
1H-Indole-7-carbonitrile, 4-fluoro-
4-FLUORO-1H-INDOLE-7-CARBONITRILE 97%
1H-Indole-7-carbonitrile,4-fluoro-(9CI) | [Molecular Formula]
C9H5FN2 | [MDL Number]
MFCD11845597 | [MOL File]
313337-33-6.mol | [Molecular Weight]
160.15 |
| Chemical Properties | Back Directory | [Boiling point ]
357.0±22.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
14.01±0.30(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Uses]
4-Fluoro-1H-indole-7-carbonitrile is used as a pharmaceutical intermediate. | [Synthesis]
Step A: A mixture of 4-fluoro-7-bromoindole (600 mg, 2.8 mmol) with cuprous cyanide (CuCN, 1.004 g, 11.2 mmol) in N,N-dimethylformamide (DMF, 4 mL) was heated and refluxed for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into a methanol solution saturated with ammonia (30 mL) and filtered to remove insoluble residues. The filtrate was subsequently added to a mixture of water (20 mL) and saturated aqueous ammonia solution (20 mL) and extracted with ethyl acetate/ether (1:1, v/v) until thin-layer chromatography (TLC) analysis showed no product residue in the aqueous phase. The organic phases were combined, washed sequentially with saturated saline (2 x 200 mL) and water (200 mL), and dried over anhydrous magnesium sulfate (MgSO4). The organic phase was concentrated under reduced pressure to afford 4-fluoro-7-cyanoindole as a yellow-brown solid (310 mg, 69% yield). | [References]
[1] Patent: US6469006, 2002, B1 |
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| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-58581007 18019463053 |
| Website: |
http://www.coolpharm.com.cn |
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