| Identification | Back Directory | [Name]
SALOR-INT L224693-1EA | [CAS]
313380-27-7 | [Synonyms]
FDI 6
FDI-6 >=98% (HPLC)
FDI 6 - NCGC 00099374
SALOR-INT L224693-1EA
FOXM1 Inhibitor III (FDI-6)
3-AMINO-N-(4-FLUOROPHENYL)-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE
Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(4-fluorophenyl)-6-(2-thienyl)-4-(trifluoromethyl)-
3-amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide
3-Amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridine-2-carboxylic acid (4-fluoro-phenyl)-amide | [Molecular Formula]
C19H11F4N3OS2 | [MDL Number]
MFCD01416826 | [MOL File]
313380-27-7.mol | [Molecular Weight]
437.43 |
| Chemical Properties | Back Directory | [Boiling point ]
533.7±50.0 °C(Predicted) | [density ]
1.562±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO:64.34(Max Conc. mg/mL);147.09(Max Conc. mM) | [form ]
powder (flocculent) | [pka]
10.24±0.70(Predicted) | [color ]
white to beige | [InChI]
1S/C19H11F4N3OS2/c20-9-3-5-10(6-4-9)25-17(27)16-15(24)14-11(19(21,22)23)8-12(26-18(14)29-16)13-2-1-7-28-13/h1-8H,24H2,(H,25,27) | [InChIKey]
ZATJMMZPGVDUOM-UHFFFAOYSA-N | [SMILES]
NC1=C(C(NC2=CC=C(F)C=C2)=O)SC3=C1C(C(F)(F)F)=CC(C4=CC=CS4)=N3 |
| Hazard Information | Back Directory | [Uses]
FDI-6 is an inhibitor of FOXM1. FDI-6 binds directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation. | [Biochem/physiol Actions]
Forkhead domain inhibitor-6 (FDI-6) is used to treat anaemia patients because of diminished red blood production. In Hep-2 cells, FDI-6 can stimulate cell death and also helps to prevent cell proliferation, invasion and migration. | [References]
[1] Gormally MV, et al. Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat Commun. 2014 Nov 12;5:5165. DOI:10.1038/ncomms6165 |
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Sigma-Aldrich
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https://www.sigmaaldrich.cn |
| Company Name: |
3A Chemicals
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400-668-9898 |
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www.3achem.com |
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