313998-81-1

Directory

313998-81-1 Structure

Identification	Back Directory
[Name] (5Z,8Z,11Z,14Z)-N-(4-HYDROXY-2-METHYLPHENYL)-5,8,11,14-EICOSATETRAENAMIDE
[CAS] 313998-81-1
[Synonyms] VDM 11 VDM 11 (in Tocrisolve 100) VDM-11 (Solution in Ethanol) VDM 11 (in Tocrisolve(TM) 100) N-ARACHIDONYL-4-HYDROXY-2-METHYLANILIN N-ARACHIDONOYL-4-HYDROXY-2-METHYLANILIN N-(4-HYDROXY-2-METHYLPHENYL)ARACHIDONYLAMIDE N-(4-HYDROXY-2-METHYLPHENYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE (5Z,8Z,11Z,14Z)-N-(4-hydroxy-2-methylphenyl)icosa-5,8,11,14-tetraenamide (5Z,8Z,11Z,14Z)-N-(4-HYDROXY-2-METHYLPHENYL)-5,8,11,14-EICOSATETRAENAMIDE 5,8,11,14-Eicosatetraenamide, N-(4-hydroxy-2-methylphenyl)-, (5Z,8Z,11Z,14Z)- N-(4-Hydroxy-2-methylphenyl)arachidonylamide, (5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide
[Molecular Formula] C27H39NO2
[MDL Number] MFCD04037552
[MOL File] 313998-81-1.mol
[Molecular Weight] 409.6

Chemical Properties	Back Directory
[storage temp. ] −20°C
[solubility ] DMSO: >5 mg/mL, soluble
[form ] oil
[color ] gold
[Stability:] Light Sensitive

Hazard Information	Back Directory
[Description] Numerous analogs of arachidonoyl ethanolamide (AEA) potentiate its biological activity. This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty amide acyl hydrolase (FAAH) within the neurons. VDM11 is an AEA transport inhibitor with essentially no activity on either the central cannabinoid receptor (CB₁), peripheral cannabinoid receptor (CB₂), or the vanilloid receptor 1 (VR1). However, VDM11 inhibits FAAH and monoacylglycerol lipase (MAGL) and may act as an alternative FAAH substrate. At a concentration of 3 μM, VDM11, like AM404, inhibits glutamergic synaptic transmission between hippocampal neurons. The mechanism of this effect may be a direct action on sodium channels. Thus, the use of anandamide analogs as uptake inhibitors and interpretation of the results must be undertaken with care.
[Uses] VDM-11 is a selective inhibitor of the anandamide membrane transporter.
[Biological Activity] A potent and selective inhibitor of the anandamide membrane transporter (AMT), in water-soluble emulsion (for details see TocrisolveTM 100). IC 50 values for inhibition of AMT are 4-11 mM. Displays negligible agonist activity at the hVR1 receptor and very weak action at CB 1 and CB 2 receptors. K i values are > 5-10 mM at CB 1 and CB 2 . Active in vivo . Also available as pure oil dissolved in ethanol ((5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide ).

313998-81-1 suppliers list

Company Name:
Tel:	821-50328103-801 18930552037
Website:	https://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm

Company Name:	Shanghai EFE Biological Technology Co., Ltd.
Tel:	021-65675885 18964387627
Website:	http://www.efebio.com

Company Name:	ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel:	18818260767
Website:	http://www.chemegen.com

Company Name:	MedBioPharmaceutical Technology Inc
Tel:	021-69568360 18916172912
Website:	http://www.med-bio.cn/

Company Name:	Santa Cruz Biotechnology Inc
Tel:	60936350
Website:	http://www.scbt.com

Tags:313998-81-1 Related Product Information

HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

Login